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SCI급 논문 기타학술지 내용
제목
Identification of an 18-Methyl Derivative of Tacrolimus API in Streptomyces clavuligerus CKD-1119
학술지 Bull. Korean Chem. Soc., 32(1), 109-112(2011)
저자명 Yun-Beom Ham and Yoon-Mo Koo
A new derivative of tacrolimus was evaluated for its molecular weight, using LC-MS of the tacrolimus bulk active
pharmaceutical ingredient (API) recovered through the purification of crude tacrolimus produced by Streptomyces
clavuligerus CKD-1119. In addition, the molecular weight of the new derivative of tacrolimus was found to be at m/z
818 and was identified by 13C-NMR with peak assignments based on the differences in methyl group location resulting
from the chemical structure. The structure of the new derivative, an unknown impurity of tacrolimus, was found to
be 18-methyltacrolimus through comparison of the spectral data of the structural differences between ascomycin,
tacrolimus, and the new derivative 18-methyltacrolimus
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